Basavaraja H S et al. (2010) Synthesis of novel piperazine and morpholine linked substituted pyrimidine derivatives as antimicrobial agents.

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Synthesis of novel piperazine and morpholine linked substituted pyrimidine derivatives as antimicrobial agents.

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CONTRIBUTORS:

	Author:	Basavaraja H S
	Author:	Jayadevaiah K.V
	Author:	Mumtaz M. Hussain
	Author:	Vijay Kumar M M J
	Author:	Basavaraj Padmashali

JOURNAL:

JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2(1), 5 - 12.

YEAR:

2010

PUB TYPE:

Journal Article

SUBJECT(S):

Pharmacy

DISCIPLINE:

Pharmacy

HTTP:

http://www.jpsr.pharmainfo.in/Documents/Volumes/Vol2Issue1/jpsr02011002.pdf

LANGUAGE:

English

PUB ID:

103-469-821 (Last edited on 2010/03/09 02:51:22 US/Mountain)

SPONSOR(S):

ABSTRACT:
Several 6-(substituted)-5-cyano-2-thiouracils 1a-d, were prepared by the condensation of different aldehydes with ethylcyanoacetate and thiourea through a single step reaction by conventional and microwave irradiation technique. The compounds 6-(substituted)-5-cyano-2-thiouracils 1a-d were further treated with methyl iodide in presence of potassium carbonate and N,N-dimethyl formamide, as solvent to get 1-methyl-2-methylthio-4- (substituted)-5-cyano-1,6-dihydropyrimidine-6-ones 2a-d. Methylated compounds were further treated with heterocyclic secondary amines like N-methylpiperazine, piperazine and morpholine to get 3a-d, 4a-d and 5a-d. All the synthesized compounds were screened for their antimicrobial activity and were characterized by elemental analyses, IR, 1H NMR and mass spectral data.

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